Table 2. Varicella Zoster Virus Prophylaxis

Indication Drug Adult Dose Duration

Primary prophylaxis

Ganciclovir

(If CMV prophylaxis indicated)

1 g PO three times a day

First 3 months post transplant

Valganciclovir

(If CMV prophylaxis indicated)

900 mg PO once a day

Acyclovir

600-1000 mg/day (over 3-5 doses)

First 6 months post transplant

(if not on CMV prophylaxis)

Valacyclovir

500 mg PO twice a day

Secondary prophylaxis

VariZIG

125 units/10 kg IM once

(625 units maximum, 125 units minimum)

Within 96 hours of exposure

IVIG

400 mg/kg IV once

After 96 hours of exposure

Acyclovir

800 mg PO Four times a day

For 7 days, starting on day 7-10

post exposure

Valacyclovir

1g PO three times a day